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Intermediate

Intermediates (Pharmaceutical Intermediates)

Pharmaceutical intermediates are chemical compounds produced during the synthesis of Active Pharmaceutical Ingredients (APIs). They are an important stage in the manufacturing process of drugs, serving as building blocks for the final API. With strict adherence to quality and regulatory compliance, pharmaceutical intermediates are manufactured under cGMP standards to ensure purity, consistency, and safety before they are further processed into APIs

Sr No Name Of API Name Of Intermediate CAS No
1 Ambroxol HCl 2‐Amino‐3,5‐Dibromo‐Benzaldehyde 50910‐55‐9
2 Amiodarone HCl 2‐Butyl‐3‐(3,5‐Diiodo‐4‐hydroxy benzoyl) benzofuran 1951‐26‐4
3 Amisulpiride 2‐(Aminomethyl)‐1‐ethylpyrrolidine 26116‐12‐1
4 Amlodipine Besilate Amlodipine Base 88150‐42‐9
5 Apixaban 3‐morpholino‐1‐(4‐(2‐oxopiperidin‐1‐yl) phenyl)‐5,6‐dihydropyridin‐2(1H)‐one 545445‐44‐1
6 Apixaban (Z)‐Ethyl 2‐chloro‐2‐(2‐(4‐methoxyphenyl)hydrazono) acetate
7 Apixaban 3‐Morpholino‐1‐(4‐nitrophenyl)‐5,6‐dihydropyridin‐2(1H)‐one 503615‐03‐0
8 Apixaban Ethyl 1‐(4‐methoxyphenyl)‐7‐oxo‐6‐(4‐(2‐oxopiperidin‐1‐yl)phenyl)‐4,5,6,7‐tetrahydro‐1H‐pyrazolo[3,4‐c]pyridine‐3‐carboxylate 503614‐91‐3
9 Apremilast 3‐Acetamidophthalic anhydride 6296‐53‐3
10 Apremilast (S)‐1‐(3‐Ethoxy‐4‐methoxyphenyl)‐2‐(methylsulfonyl)ethanamine 608141‐42‐0
11 Aripiprazole 7‐(4‐Bromobutoxy)‐3,4‐dihydro‐2(1H)‐quinolinone 129722‐34‐5
12 Atorvastatin Tert‐Butyl(4R,6R)‐2‐[[[6‐(2‐4‐fluorophenyl)‐5‐ isopropyl‐3‐phenyl‐4‐(phenylcarbamoyl) pyrrol‐1‐yl]ethyl]‐2,2‐dimethyl‐1,3dioxan‐4‐yl]acetate 125971‐95‐1
13 Atorvastatin Diketone (4 Fluoro‐a‐[2‐methyl‐1‐oxopropyl]‐y,b‐bisphenylbenzene butaneamide) 125971‐96‐2
14 Bendamusitn HCl Ethyl4‐(5‐amino‐1‐methyl‐1H‐benzo[d]imidazole ‐2‐yl)butanoate 3543‐73‐5
15 Bupropion 3’‐Chloropropiophenone 34841‐35‐5
16 Carvedilol 4‐(2,3–Epoxy Propoxy) Carbazole 51997‐51‐4
17 Celecoxib 1‐(4‐Methylphenyl)‐4,4,4‐Trifluoro‐butane‐1,3‐Dione 720‐94‐5
18 Cetrizine 1‐(4‐Chloro Benzhdryl) Piperazine 303‐26‐4
19 Chlorpromazine 2‐Chlorophenothiazine 92‐39‐7
20 Clopidogrel S‐(+) ‐ Methyl‐(2‐Chlorophenyl)[(2‐(2‐thienyl)amino 141109‐19‐5
21 Clopidogrel Methyl‐(4,5,6,7‐tetrahydro‐5‐thieno [3,2‐c] pyridyl) (2‐chlorophenyl) acetatehydrochloride 144750‐52‐7
22 Clopidogrel S(+)‐2‐(2‐Chloropheny)‐6,7‐dihydrothieno (3,2‐ C)pyridine‐5(4H)‐acetic acid methyl ester camphorsulfonate 120202‐68‐8
23 Dabigatran N‐(4‐cynophenyl)‐glycine 42288‐26‐6
24 Dabigatran N‐[3‐Amino‐4‐(methyl amino)benzoyl]‐N‐2‐pyridinyl‐ ethyl ester 212322‐56‐0
25 Dabigatran 2‐(4‐Cyanophenylamino) Acetic acid 42288‐26‐6
26 Dabigatran Ethyl 3‐(2‐(((4‐cyanophenyl) amino) methyl)‐1‐methyl‐ N‐pyridin‐2‐yl)‐1H‐benzo[d]imidazole‐5‐carboxamido) propanoate 211915‐84‐3
27 Dabigatran Ethyl 3‐2‐(4‐amidinophenylamino) methyl)‐1‐methyl‐ N‐(pyridin‐2yl)‐1H‐benzo[d]imidazole‐5‐carboxamido) propanoate 429658‐95‐7
28 Dabigatran Ethyl 3‐{[(2‐{[(4‐{N'‐[(Hexyloxy) carbonyl] carbamimidoyl} phenyl) amino]methyl}‐l‐methyl‐ lH‐ benzimidazol‐5‐yl)carbonyl] (2‐pyridinyl)amino} propanoate 211915‐06‐9
29 Dabigatran Ethyl 3‐[[2‐[[4‐(E)‐N1‐hexyloxycarbonyl carbamimidoyl] aniline] methyl]‐1‐methylbenzimidazole‐5‐carbonyl] pyridin‐2‐ylamino] propanoate 1408238‐36‐7
30 Deferasirox 2‐(2‐Hydroxy phenyl)benz(e)[1,3]‐oxazin‐4‐one 1218‐69‐5
31 Deferasirox 4‐hydrazino benzoic Acid 619‐67‐0
32 Doxazosin Mesylate N‐(1,4‐Benzodioxan‐2‐carbonyl)piperazine 70918‐00‐2
33 Doxazosin Mesylate 4‐Amino‐2‐chloro‐6,7‐dimethoxyquinazoline 23680‐84‐4
34 Edoxaban 2‐[(5‐chloropyridin‐2‐yl)amino]‐2‐oxoacetic acid ethyl ester 1243308‐37‐3
35 Edoxaban Ethyl oxalyl chloride 125542‐74‐7
36 Eletriptan Hydrobromide (R)‐5‐Bromo‐3‐((1‐methyl‐2‐pyrrolidinyl)methyl]‐1H‐indole 143322‐57‐0
37 Eletriptan Hydrobromide Eliglustat 29668‐44‐8
38 Eletriptan Hydrobromide 2,3‐dihydrobenzo[b][1,4]dioxine‐6‐carbaldehyde
39 Esomeprazole Magnesium 6‐Methoxy‐2‐[(S)‐[(4‐methoxy‐3,5‐dimethyl‐2‐ pyridinyl)methyl]sulfinyl]‐1H‐benzimidazole potassium salt (1:1) 161796‐84‐5
40 Etoricoxib [Ketosulfone] 1‐(6‐methylpyridin‐3‐yl)‐2‐[4‐(methylsulfonyl) phenyl]ethanone 221615‐75‐4
41 Famotidine S‐(2‐Guanidino)‐Thiazol‐4‐yl‐methyl‐isothiourea dihydrochloride (FAM‐I) 88046‐01‐9
42 Famotidine N‐sulfamyl‐3‐chloropropionamidine hydrochloride (FAM‐II) 106649‐95‐0
43 Febuxostat Ethyl 2‐(3‐cyano‐4‐isobutoxyphenyl)‐4‐methyl‐5‐thiazolecarboxylate 160844‐75‐7
44 Flecainide 2,5‐Bis(2,2,2‐trifluoroethoxy)benzoic acid 35480‐52‐5
45 Fluconazole 2,4-Difluoro-1H,1H-1,2,4-triazole Acetophenone (DFTA) 51336‐94‐8
46 Fluvoxamine Maleate 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone 61718-80-7
47 Glibenclamide Sulphonamide of Glibenclamide 16673-34-0
48 Glimepiride Glimepiride Sulfonamide 119018-29-0
49 Glipizide 4-(2-aminoethyl)benzene sulfonamide 35303-76-5
50 Ibandronate 3-(N-Methyl-N-Pentyl amino)propionic acid HCl 625120-81-2
51 Ilaprazole 2-(Chloromethyl)-4-methoxy-3-methylpyridine hydrochloride 86604-74-2
52 Itraconazole 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1 methylpropyl)-3H-1,2,4-triazol-3-1 106461-41-0
53 Itraconazole (Cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methane sulphonate 67914-86-7
54 Ivacaftor 4-oxo-1,4 dihydroquinoline-3-carboxylic acid 13721-01-2
55 Ketoconazole Cis Bromo Benzoate 61397-56-6
56 Ketorolac Diethyl Cyclopropane-1,1-Dcarboxylate 1559-02-0
57 Labetalol HCl 5-Bromoacetyl Salicylamide 2-(2,3-Dichlorophenyl)-2-(guanidinylamino)acetonitrile 73866-23-6
58 Lamivudine 2,2-Dihydroxy- acetic acid-(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester (LVC-1) 111969-64-3
59 Lamotrigine 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl]methyl]thio]-1H-benzimidazole 84689-20-3
60 Lansoprazole 2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride (Lansochloro) 127337-60-4
61 Lansoprazole 2-mercaptobenzimidazole 583-39-1
62 Lansoprazole 2-[[[3-Methyl-4-(222-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazole 103577-40-8
63 Levocetrizine (-) -1-[4-(Chlorophenyl)phenyl Methyl] piperazine 130018-88-1
64 Levosulpiride 2-methoxy-5-sulfamoyl methyl benzoate 33045-52-2
65 Linagliptin 4-Nitrophenethylamine hydrochloride 668273-75-4
66 Loratadine N-Methyl Desloratadine 38092-89-6
67 Lornoxicam 6-Chloro-hydroxy-2-methyl-N-2-Pyridinyl-2H-thieno-[2,3-e)-1,2-thiazine-3-carboxamide 1,1 dioxide (LXM-1) 70374-51-5
68 Losartan Potassium 2-n-Butyl-4-chloro-5-formyl-1-H-imidazole(BCFI) 83857-96-9
69 Memantine HCl 1-Acetamido-3,5-dimethyladamantane 19982-07-1
70 Miconazole 1-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-yl)ethanol 24155-42-8
71 Mirabegron 2-(4-nitrophenyl)ethanamine hydrochloride 29968-78-3
72 Mirabegron 2-Aminothiazol-4-acetic acid Hydrochloride 29676-71-9
73 Mirabegron (R)-2-Hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide 66659-20-9
74 Olanzapine Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride 138564-60-0
75 Omeprazole 2-chloromethyl-3 5-dimethyl-4-methoxy pyridine hydrochloride (Omechloro) 86604-75-3
76 Omeprazole 5-methoxy-2-((4-methoxy-3 5-dimethylpyridin-2-yl)methylthio)-1h-benzimidazole 1346599-85-6
77 Omeprazole 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) 73590-85-9
78 Oseltamivir Phosphate Ethyl (3R, 4S, 5S)- 4,5-epoxy-3-(1-ethyl-propoxy) cyclohex-1-ene-1-carboxylate 204254-96-6
79 Paliperidone 2-Amino-3-benzyloxypyridine 24016-03-3
80 Pantoprazole Sodium 5-Difluoromethoxy-2-{[(3, 4-dimethoxy-pyridin-2- yl)methyl]thio}-1H -benzimidazole 102625-64-9
81 Paroxetine HCl N-Methyl Paroxetine 110429-36-2
82 Paroxetine HCl (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine 105812-81-5
83 Perampanel 5'-bromo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one 381248-06-2
84 Pioglitazone 5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione 111025-46-8
85 Pirfenidone 5-Methylpyridin-2(1H)-one 1003-68-5
86 Prasugrel 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
87 Prasugrel 5,6,7,7a-Tetrahydrothieno(3,2-c]pyridine-2(4H)-onehydrochloride 115473-15-9
88 Pregabalin 3-(Carbamoyl)-5-Methyl Hexanoic Acid 181289-33-8
89 Quetiapine Dibenzo[B,F][1,4]-Thiazepin-11(10H)-one 460029
90 Rabeprazole Pyridine 4-chloro-2,3-dimethyl) 1- oxide 59886-90-7
91 Rabeprazole 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2- yl]methylthio}-1H-benzimidazole (Rabe Sulphide) 117977-21-6
92 Racecadotril 2-Benzyl acrylic acid 5669-19-2
93 Raloxifene 2-bromo-4-methoxyacetophenone 2632-13-5
94 Raloxifene 6-methoxy-2-(4-methoxyphenyl)benzo [b] thiophene 63675-74-1
95 Raloxifene 4-(2-(piperidin-1-yl)ethoxy)benzoic acid hydrochloride 84449-80-9
96 Raltegravir Methyl 2-[(benzyloxy)carbonyl]amino]-1-methylethyl]-1-methyl-5-hydroxy-6-Oxo-1,6-dihydroxy pyrimidine-4-carboxylate 888504-27-6
97 Raltegravir Benzyl [1-(4-[(4-fluorobenzyl)amino]carbonyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-1-methylethyl]carbamate 518048-02-7
98 Raltegravir 5-Methyl-1,3,4-oxadiazole-2-carboxilic acid potassium salt 888504-28-7
99 Ranolazine 1-[N-(2,6-Dimethylphenyl)carbamoyl methyl]piperazine 5294-61-1
100 Ranolazine 1-(2-Methoxyphenoxy)-2,3-epoxypropane 2210-74-4
101 Risedronate Sodium 3-pyridylacetic acid hydrochloride 6419-36-9
102 Rivaroxaban 4-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone 446292-08-6
103 Rivaroxaban 4-(4-aminophenyl)morpholin-3-one 438056-69-0
104 Rivaroxaban S(+) -Glycidyl phthamide 161596-47-0
105 Rivaroxaban 5-chlorothiophene-2-carboxylic acid 24065-33-6
106 Rivaroxaban 2-[(2R)-2-Hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione 446292-07-5
107 Rivaroxaban (S)-2-((2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione 446292-08-6
108 Rivaroxaban 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone Hydrochloride 898543-06-1
109 Roflumilast 3,4 Dihydroxy Benzaldehyde 139-85-5
110 Sertraline Cis-Sertraline Mandalate 79617-97-3
111 Sevelamer Poly(allylamine hydrochloride) 71550-12-4
112 Solifenacin 3-Quinuclidinone hydrochloride 1193-65-3
113 Tadalafil 1,2,3,4-Tetrhydro-2-chloroacetyl-1-(3,4-methylene dioxyphenyl)-9H-pyrido[3,4-B]indole-3-carboxylate 171489-59-1
114 Telmisartan 3'2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-1H-benzimidazole 152628-02-9
115 Teneligliptin 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine 401566-79-8
116 Teneligliptin (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester 401564-36-1
117 Terbutaline 3,5-dibenzyloxy acetophenone 28924-21-2
118 Terbutaline 3,4-Dihydro-6-methyl-3-methyl pyridine HCl 403612-90-8
119 Topiramate Diacetone fructose 20080-92-6
120 Torsemide 4‐(3‐Methyl Phenyl) Amino‐3‐Pyridine Sulfonamide 72811‐73‐5
121 Valacyclovir HCl 2‐[(2‐amino‐1,6‐dihydro‐6‐oxo‐9H ‐purin‐9‐yl) methoxy] ethyl N‐[(phenylmethoxy)carbonyl]‐L‐ valinate 124832‐31‐1
122 Voriconazole 1‐(2,4‐Difluorophenyl)‐2‐(1H‐1 ,2,4‐triazole‐1‐yl) ethanone 86404‐63‐9
123 Voriconazole 4‐chloro‐6‐ethyl‐5‐fluoropymidine 137234‐74‐3
124 Zaleplon 3‐Aminopyrazole‐4‐carbonitrile 16617‐46‐2
125 Zoledronic Acid Imidazole‐1yl‐acetic acid 22884‐10‐2
126 Other Intermediate 1,4 Butane Disulhonate
127 Other Intermediate 2,3-Dichloro Benzoyl Cyanide
128 Other Intermediate 4-TER-BUTYL-4-CHLOROBUTYROPHENONE